Elevated Levels of Vitamin B12 in Gastro Intestinal, Pancreatic and Hepatobiliary Malignancies
Abstract: Background: Vitamin B12 is an organic compound essential for DNA synthesis, DNA methylation and mitochondrial metabolism. Deficiency states are common. Increased levels of B12 are rare but may be seen in certain conditions like chronic liver disease, chronic kidney disease, certain inflammatory conditions, myeloproliferative diseases and solid organ cancers. Aim: To assess the frequency of elevated serum B12 in various GI hepatobiliary and pancreatic malignancies. Methods and Materials: One hundred patients with cancer and one hundred controls were assayed for serum B12. Test procedure was performed with CLIA VITROS integrated system. Subjects who were administered oral & parenteral B12 in past 3 months were excluded from study. Based on serum B12, subjects were divided into 2 groups (less than 1000 pg/ml and more than 1000 pg/ml). Statistical Analysis: Chi square test, one way ANOVA and software SPSS version 23 was used. Confidence interval was 95% and p value
Keywords: Hypervitaminosis, Cancer, Methylcobalamin, Pernicious anemia, Neuropathy, Intrinsic factor
How to Cite?: Ravi Shankar B, Shruti Sagar B, Kiran Kumar J, Madhavi Devalaraju, Vamsi Krishna Bodireddy, Madhusudhan E, Sayeeda Asma Sultana, Devasree C. Srinivasulu, Jangeer Bee, "Elevated Levels of Vitamin B12 in Gastro Intestinal, Pancreatic and Hepatobiliary Malignancies", Volume 14 Issue 12, December 2025, International Journal of Science and Research (IJSR), Pages: 571-574, https://www.ijsr.net/getabstract.php?paperid=SR251128150318, DOI: https://dx.doi.org/10.21275/SR251128150318