Biodegradable Polymer Based Nanogels: Platform for Drug Delivery System

Anu Paul P., Smitha K Nair, Dineshkumar B, Krishna Kumar

Abstract: Hydrogel with three - dimensional (3D) tunable porous structure are known as nanogels having particle size range of 1 to 100 nm and used as drug delivery carrier. Nanogels can be used to encapsulate small drug molecules, oligonucleotides, and proteins. They are made of a variety of natural or synthetic polymers. Because of its 3D structure, which allows for the encapsulation of hydrophobic or hydrophilic pharmaceuticals in their internal network, nanogels are able to retain their highly hydrated nature and shrinking - swelling capabilities, potentially safeguarding these drugs from deterioration during storage. Additionally, by altering their surface, nanogels can be made to be more targeted and multifunctional, and their circulation time can be extended. Currently, drug delivery systems based on nanogel have gained popularity and made a big effect due to their pharmacological uses. In this review article, we summarize an overview of the development of different bioploymeric nanogels and their use in drug delivery systems.

Keywords: Nanogels, Drug Delivery, Topical, Polymers, Nanogel structure