Evaluation of Effect of Repeated Heated Sesame Oil on Hematology and Vital Organs of Wistar Male Rats

Mujeeda Banu

Abstract: Sesame oil (SO) is known for the natural antioxidants present in it and their advantages. Upon thermal treatment the activity of antioxidants varies and toxicity may be developed in the oils. The purpose of this study is to know the toxic behavior of repeatedly heat treated sesame oil with and without synthetic antioxidant, tertiary butyl hydroquinone (TBHQ) on Wistar rats. SO with and without synthetic antioxidants was heated at 180 ? 100 C for 16 hrs and physico - chemical changes of the oils were studied. The effects of repeatedly heated oil on the vital organs of wistar male rats were investigated. The ground standard rat chows (Gold Coin Sdn Bhd, Malaysia) were mixed with thermal treated SO and fed to the rats for 30 days. Twenty - four male wistar rats were divided into four groups, control rats (CR), fresh SO (SOR), repeated heated SO (HSOR) and repeated heated SO containing 200 ppm TBHQ (HSOQR) fed rats. After one month, the rats were sacrificed and hematological tests of the heart, kidney and liver tissues were carried out along with histological study. It is found that, in SOR groups, there were no significant variations in hematology tests and damage in the heart, kidney and liver tissues, whereas the damage were found to be more significant in HSOR and HSOQR rat groups. Also the deleterious effects were more in rats consuming repeatedly heated SO without synthetic antioxidant.

Keywords: Wistar male rats ? Sesame oil ? Repeatedly heated oil ? TBHQ ? Hematology

How to Cite?: Mujeeda Banu, "Evaluation of Effect of Repeated Heated Sesame Oil on Hematology and Vital Organs of Wistar Male Rats", Volume 13 Issue 9, September 2024, International Journal of Science and Research (IJSR), Pages: 962-969, https://www.ijsr.net/getabstract.php?paperid=SR24916010330, DOI: https://dx.doi.org/10.21275/SR24916010330