A Successful Outcome in Pregnancy in a Patient with both Antiphospholipid Antibody Syndrome and Protein S Deficiency

Leena Awasthi Kapur, Sunil V. Kapur

Abstract: Antiphospholipid syndrome (APS) is known to be associated with poor fetal outcomes. Although the evidence is inconclusive, inherited thrombophilias, including protein S deficiency, also contribute to poor pregnancy outcomes. Protein S is a vitamin K - dependent anticoagulant that plays an important role in regulating clotting. Protein S deficiency can cause thromboembolism and recurrent miscarriages. We present a case study of a woman with a history of two abortions who was diagnosed with both antiphospholipid antibodies and protein S deficiency and was treated with aspirin and low - dose hydroxychloroquine. After treatment, the woman became pregnant and delivered a healthy male baby at 36 weeks of gestation. This case describes the pathogenesis and treatment of APS and protein S deficiency in the setting of recurrent miscarriage, focusing on clinical and clinical management.

Keywords: Antiphospholipid syndrome, Protein S deficiency, Recurrent miscarriage