A Comparative Study on Two Doses of Esmolol 0.5mg/Kg and 1.5mg/Kg to Attenuate the Hemo Dynamic Stress Response during Laryngoscopy and Endo Tracheal Intubation

Dr Subramanya K, Dr Kilaparthi Teja, Dr Karuna Kumar Das

Abstract: This study investigates the optimal dose of esmolol to attenuate the hemodynamic response to laryngoscopy and endotracheal intubation. Conducted over six months at a tertiary healthcare center, 40 patients undergoing general surgical procedures were divided into two groups receiving either 0.5 mg/kg or 1.5 mg/kg of esmolol. Heart rate and blood pressure were monitored at baseline, during, and after intubation. The results showed that a 1.5 mg/kg dose of esmolol significantly reduced the increase in heart rate and blood pressure compared to the 0.5 mg/kg dose. The higher dose was more effective in minimizing the hemodynamic stress response, with no major side effects reported.

Keywords: Esmolol, Hemodynamic response, Laryngoscopy, Endotracheal intubation, Beta-blockers