Transition Metal Oxide (TiO2) Catalyst Promoted by the Synthesis of Imidazoles

P. Shyam Sundar, Dr. N. Krishnarao

Abstract: A one pot, three-component condensation of benzil, substituted aromatic aldehydes, and ammonium acetate using as a mild oxidant is achieved to form trisubstituted imidazole compounds. A series of 2, 4, 5-triarylimidazole derivatives are obtained from the simple and highly efficient three components such as benzil, aromatic aldehydes and ammonium acetate promoted by TiO2 in presence ethanol solvent. The study explores the scope and limitation of TiO2 as an oxidant and suggests advantages, viz., simplicity of operation, reduction in time, and an increase in product yields. These are used in the catalysis. This reaction produces the 2, 4, 5-triarylimidazole derivatives with good yield and purity. The newly synthesized derivatives determined by advanced spectroscopic data viz; IR, 1HNMR, 13CNMR and LCMS and also determined by elemental analysis.

Keywords: Multicomponent reactions (MCRs), Benzil, benzaldehyde, NH4OAc, 2, 3, 4 -trisubstituted Imidazole, TiO2