International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Neurology | Indonesia | Volume 13 Issue 4, April 2024


Predictor Factors for the Incident of Delirium in Sepsis at Prof. Dr. Igng Ngoerah Denpasar Period January 2022 to August 2023

I Wayan Widyantara | Anak Agung Derisna Citra Saraswati


Abstract: Background: Delirium are disturbances in the function of consciousness, attention, perception, thinking, memory, psychomotor, emotions, and sleep - wake patterns. The mechanisms and predictor factors underlying delirum in sepsis are currently still unclear, but based on neurological clinical observations in patients with chronic sepsis, delirium in sepsis is a combination of neuroinflammation, impaired cerebral perfusion, impaired blood - brain barrier and neurotransmission. The aim of this study was to determine predictor factors in patients with delirium in sepsis at Prof. Dr. IGNG Ngoerah Denpasar for the period January 2022 to August 2023. Methods: An observational study on relationship of several clinical parameters and the severity all patients with sepsis, both with delirium and without delirium, who are treated in the room by the Neurology department in collaboration with the Psychiatry department at Prof. IGNG Ngoerah General Hospital Denpasar for the period January 2022 to August 2023. Delirium was defined by the Memorial Delirium Assessment Scale (MDAS) and predicting mortality use Chalson Age Comorbidity Index (CCI) scores. Results: Over 18 months, there were 62 patients with sepsis, both with and without delirium, who were treated in the room by the Neurology department in collaboration with the Psychiatry department at Prof. Dr. Dr. IGNG Ngoerah General Hospital Denpasar for the period January 2022 to August 2023. Overall, 35 (56.45%) patients were male and 27 (43.55%) patients were female. Where 49 (79.03%) patients had delirium and 13 (20.97%) patients without delirium. Overall, 35 (56.0%) patients had pneumonia, 16 (25.8%) patients had UTI, and 11 (17.7%) patients had other infections, and 49 of 62 (79%) patients had sepsis. In this study, there were no significant differences in MDAS scores between male and female patients and among different types of infections, but patients with sepsis had significantly higher MDAS scores compared with patients without sepsis (19.48? 3.72 vs 15.88?2.82; P<.001). This study revealed that of several clinical variables, only BUN (R= 0.230; P=0.040) and CCI (R= 0.533; P<0.001) correlated with MDAS score significantly in Table 3. By multiple linear regression test, CCI and sepsis had a significant role, while BUN had no role in delirium severity. Conclusions: the CCI score and sepsis has a strong relationship with the severity of delirium, only BUN levels have a weak role in the severity of delirium.


Keywords: Delirium, sepsis, predictor factors


Edition: Volume 13 Issue 4, April 2024,


Pages: 1238 - 1240


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