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Review Papers | Health Sciences | India | Volume 13 Issue 3, March 2024
Tirzepaptide: A Promising Option for Treating Obesity and Overweight
Dr. Manoj Kumar Saurabh | Dr. Amit Ranjan
Abstract: The Food Drug Administration (United State of America) approved tirzepatide injection in November 2023 for long - term weight management in adults with obesity or overweight and weight - related conditions like high blood pressure, type 2 diabetes, or high cholesterol. It is a 39 - amino acid synthetic peptide, induces insulin secretion, decreases hyperglycemia, and increases adiponectin levels, suppressing appetite more effectively than long - acting glucagon - like peptide - 1 (GLP - 1) agonist compounds alone. Clinically meaningful weight reduction observed with trizepatide. Type 2 diabetes (T2D) and obesity are chronic conditions that cannot be cured but can be controlled via therapy, lifestyle modifications, and medical intervention. Drug's weekly dosing schedule improves patient compliance and adherence, making it a promising option for treating obesity and weight reduction in Indian patients. Safety profile is also favours this drugs, gastrointestinal discomfort was the most common adverse event Undoubtedly, the evident superiority of dual incretin agonist tirzepatide over GLP - 1 will reignite interest in the therapeutic possibilities of GIP in the context of type 2 diabetes, obesity, and associated comorbidities.
Keywords: tirzepatide, Obesity, adiponectin long-acting glucagon-like peptide-1
Edition: Volume 13 Issue 3, March 2024,
Pages: 600 - 602