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India | Medical Science | Volume 13 Issue 3, March 2024 | Pages: 223 - 224
Cachexia: An Unsolved Puzzle
Abstract: APS type 1 (APS - 1) is a rare, autosomal recessive inherited disorder encompassing chronic mucocutaneous candidiasis, hypoparathyroidism, and autoimmune adrenal insufficiency, with the presence of two of these being essential for diagnosis. APS - 1 primarily affects young patients, both males and females equally. The pathogenesis of the syndrome involves the development of T cells with a high affinity to auto antigens; a defect in the body?s immune system fails to eliminate these T cells, and thus they bind to and attack the host?s cells. Apart from the manifestations listed above, APS - 1 patients can also develop hypogonadism, vitiligo, chronic diarrhea and gastritis, autoimmune hepatitis, autoimmune hypothyroidism, type 1 diabetes mellitus, and pituitary failure.
Keywords: Autoimmune polyglandular syndrome, mucocutaneous candidiasis, T cells, cortisol, adrenal insufficiency
How to Cite?: Mohammed Shanil P, Farsana Jasmin K, "Cachexia: An Unsolved Puzzle", Volume 13 Issue 3, March 2024, International Journal of Science and Research (IJSR), Pages: 223-224, https://www.ijsr.net/getabstract.php?paperid=SR24304013054, DOI: https://dx.doi.org/10.21275/SR24304013054