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Comparative Studies | Dermatology | India | Volume 13 Issue 3, March 2024
A Randomized Control Trial to Compare the Efficacy and Safety of 40% Mandelic Acid Peel with 30% Salicylic Acid Peel in Acne Vulgaris
Dr. M P Sankeerthana [2] | Dr. Shea Sharma Bhaskara Babu | Dr. Jayakar Thomas [6]
Abstract: Introduction: Acne is a common inflammatory disorder of the pilosebaceous unit and the disease runs a chronic course. Multiple modalities of management are available for acne vulgaris which includes topical therapy, systemic therapy, chemical peels, microdermabrasion, intralesional steroids and light therapies. Chemical peel with salicylic acid is an excellent keratolytic agent used in acne. Mandelic acid which is a superficial chemical peel is gaining momentum for the treatment of Acne vulgaris. Hence this study is being done to compare the therapeutic efficacy and safety of 40 % Mandelic acid peel with standard 30% salicylic acid peel in Acne vulgaris. Objective: To assess the therapeutic effectiveness, safety and side effects of 40% Mandelic acid peel in Acne vulgaris and to compare it with the standard 30% Salicylic acid peel. Study Design: An open labelled, single blinded, randomized control comparative study. Study population: Patients with Acne vulgaris Grade I-III presenting to Department of Dermatology, Venereology and Leprosy, Chettinad hospital and research institute, Kelambakkam. Duration of the study: 1 year (February 2021 to February 2022). Materials and Methods: A total of 100 patients were included in this study. Patients were divided into 2 groups, Group A and Group B. Group A patients received 30% Salicylic acid peel every 2 weeks once for 8 weeks in OPD which was neutralised with water after frosting was seen followed by broad spectrum sunscreen application. Group B patients received 40% Mandelic acid peel every 2 weeks once for 8 weeks in OPD which was neutralised with water after 2 minutes of application followed by sunscreen application. Lesion reduction was calculated using MSI (Michaelson severity Index score), subjective and objective evaluation and photographic comparison on each follow up. Results: Out of 100 patients, 86 patients completed the study. Majority of the patients belonged to 18-22 years age bracket proving acne is a disorder of adolescents and young adults. Most of the patients in our study were females. Study population treated with 30% Salicylic peel had significant reduction in MSS index compared to patients treated with 40% Mandelic peel. The safety and tolerability was better seen with 40% Mandelic acid peel. Further studies with higher number of peeling sessions should be done to evaluate the true efficacy of 40% Mandelic acid in Acne vulgaris. Conclusion: Despite better safety and tolerability of 40% Mandelic acid amongst the study population, 30% Salicylic acid showed better efficacy in clearing acne lesions.
Keywords: Acne vulgaris, Salicylic acid, Mandelic acid
Edition: Volume 13 Issue 3, March 2024,
Pages: 1624 - 1631