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Research Paper | Genetics | India | Volume 13 Issue 4, April 2024
Allergic Chronic Rhinosinusitis: A Look at NAT2A Gene Polymorphisms
Madhavi Jangala | Raja Meghanadh Koralla | Santoshi Kumari Manche | Pardhananda Reddy Penuguluru | Shehnaz Sultana | Sunita Giri Kumar | Jyothy Akka
Abstract: Recent studies exploring the genetic factors associated with allergic chronic rhinosinusitis are of great importance. However, the role of NAT2A polymorphism in CRS remains relatively understudied. To address this gap in knowledge, we conducted a research study examining the association between NAT2A polymorphism and allergic chronic rhinosinusitis. Our study aimed to investigate the prevalence of NAT2A polymorphisms in patients with allergic chronic rhinosinusitis (n=124) and Controls (n=175) to determine whether these genetic variations are linked to the development and severity of the condition. We recruited a sample of patients diagnosed with allergic chronic rhinosinusitis and genotyped them for NAT2A polymorphisms. Additionally, we collected data on their symptoms, comorbidities and disease severity. Our findings revealed a significant association between NAT2A polymorphism and allergic chronic rhinosinusitis. GA and AA genotype of Taq I 590 G>A (rs 1799930 Arg197Gln) indicated a risk of 4 times to 3 times in allergic CRS subjects. Further, the haplotype NAT2*6A NAT2*7A genotype, associated with slow acetylation was a significant risk of 2 folds for allergy. Specifically, we found that individuals with slow variants of the NAT2A gene were more likely to develop allergic chronic rhinosinusitis.
Keywords: Allergic chronic rhinosinusitis, NAT2A polymorphism, genetic association, disease severity, slow acetylation variants
Edition: Volume 13 Issue 4, April 2024,
Pages: 401 - 407