Synthesis, Spectral Characterization, Thermal and Biological Studies of Fe(III), Co(II), Cu(II), Mn(III), Cr(III) and Vo(IV) Complexes of Thiocarbohydrazone Ligand

S. B. Rathod, P. R. Mandlik

Abstract: N',2-bis((E)-2-hydroxy-3-methoxybenzylidene) hydrazine-1-carbothiohydrazide and its metal complexes with Fe(III), Co(II), Cu(II), Mn(III), Cr(III) and VO(IV) were synthesized. Elemental analysis, 1H NMR, ESR, Infrared spectra, magnetic measurements, molar conductance, mass spectra, and thermal investigations (DTA & TGA) were used to characterize the synthesized complexes. Molar conductance analysis reveals that none of the developed complexes was naturally electrolytes. The spectroscopic results revealed the ligand's behavior toward metal ions, where the complex coordination numbers were shown to be between four and six. The water molecule loss out or in of the coordination domain is shown by the thermogravimetric measurement of complexes. Calculations of the free energy, activation energy, and reaction pattern of the complexes were made using the weight change as a function of temperature. The synthesized ligand and its complexes exhibited significant antimicrobial activity.

Keywords: Thiocarbohydrazide, Metal complexes, IR, TGA, Electronic Spectra, Biological activity