Innovative Formulations to Enhance Stability and Solubility of Amphotericin-B

Pooja Dangi

Abstract: Amphotericin B (AmB) is a polyene antifungal agent that is widely used in clinical practice for the treatment of severe fungal infections. Despite its effectiveness, AmB exhibits poor solubility in water and is prone to degradation, which limits its therapeutic applications. This paper reviews various strategies employed to enhance the solubility and stability of Amphotericin B, focusing on formulation techniques, complexation methods, and novel drug delivery systems. By addressing these challenges, we aim to improve the bioavailability and clinical efficacy of Amphotericin B. This article reflects the current strategies targeting the solubility and stability enhancement of Amphotericin B, aiming to improve its clinical application and patient outcomes.

Keywords: Amphotericin B (AmB), Cyclodextrins (CDs), hydroxypropyl - beta - cyclodextrin (HP?CD), poly (lactic - co - glycolic acid) (PLGA), nanoparticles (NPs), methoxy poly (ethylene glycol) - block - poly (lactic acid) (mPEG - PLA), central nervous system (CNS)