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Research Paper | Pathology | India | Volume 13 Issue 1, January 2024
Cytological Spectrum of Body Fluids in Tertiary Care Centre
Aishwarya Wankhade | Rakesh Shedge [2] | Vrushali Patil [3]
Abstract: Introduction: IAC was published in year 2020 for establishing uniform reporting system of serous effusion and to provide a standard format for effusion cytopathology to attain uniformity across all labs. Objective: The present study is carried out to categorize serous effusions and estimate risk of malignancy (ROM) by adhering to IAC guidelines. Method: The study includes 236 body fluids (ascitic fluid, pleural fluid, pericardial, CSF) received in cytology section of Pathology Department in Nair Hospital in year 2022. The samples are centrifuged and sediment is transferred on two glass slides. One stained with May-Grunwald Geimsa stain, other with Papanicolaou stain. The stained smears are studied under microscope and evaluated. Cell blocks and histopathology are referred wherever available. Results: Our study shows a slight female predominance (1.1:1) with maximum cases in age range of 41-60yrs. Pleural fluids comprised majority of cases (52.6%), followed by ascitic fluids (41.2%) and CSF (0.6%). Majority cases had non-malignant etiology (79%). Lymphocytic (72.6%, 47.3%), neutrophilic (19.0%, 40.3%), eosinophilic predominance (1.1%, 1.7%) and mixed cell infiltrate (7.1%, 10.5%) were seen in pleural and ascitic fluid respectively.20 cases each of pleural and ascitic fluids contributed to the 21% of fluids with malignant etiology. Malignant fluids were reported as atypical cells seen (42.5%), positive for adenocarcinoma (25%), suspicious for `malignancy (15%), signet ring cells seen (10%), neoplastic squamous cells seen (5%) and malignant round cells seen (2.5%). Conclusion: Cytological analysis of body fluids is acknowledged as a prompt method to simplify further clinical management of patients.
Keywords: body fluids, malignant, non-malignant
Edition: Volume 13 Issue 1, January 2024,
Pages: 1301 - 1305