Comparison of Oxytocin versus Carbetocin in Vaginal Delivery - A Randomised Controlled Study
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 5 | Views: 94 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2

Analysis Study Research Paper | Obstetrics and Gynecology | India | Volume 13 Issue 12, December 2024 | Popularity: 5.5 / 10


     

Comparison of Oxytocin versus Carbetocin in Vaginal Delivery - A Randomised Controlled Study

Dr. Akanksha, Dr. Parul Prakash, Dr. Rupal Gandhi


Abstract: Background: Postpartum hemorrhage (PPH) is a leading cause of maternal mortality globally, especially in low - resource settings. Oxytocin is widely used to prevent PPH but has limitations, including its short half - life and need for continuous infusion and refrigeration. Carbetocin, a long - acting synthetic analogue of oxytocin, addresses these issues by offering a longer half - life and stability at room temperature, making it suitable for use in diverse clinical settings. However, data comparing oxytocin and carbetocin in vaginal deliveries is limited. Aim and Objectives: This study aimed to compare the efficacy of intravenous oxytocin (10 IU) versus intravenous carbetocin (100 mcg) in reducing postpartum blood loss and preventing PPH in vaginal deliveries with high - risk factors. Material and Method: A randomized controlled study was conducted at a tertiary care hospital in Rajasthan, India. A total of 120 women with at least one high - risk factor for PPH were randomized into two groups. Group A received 10 IU of oxytocin, and Group B received 100 mcg of carbetocin at delivery. The primary outcome was blood loss during the postpartum period, while secondary outcomes included hemoglobin drop, need for additional uterotonics, and blood transfusion. Results: The average blood loss was significantly lower in the carbetocin group (181.33 mL) compared to the oxytocin group (256.75 mL, p=0.02). The hemoglobin decrease was smaller in the carbetocin group (1.08 g/dL vs.1.34 g/dL, p=0.0001). Fewer patients in the carbetocin group required additional uterotonics (13.33% vs.30%, p=0.046) and blood transfusions (0% vs.10%, p=0.036). Conclusion: Carbetocin is more effective than oxytocin in reducing postpartum blood loss and the need for additional interventions in vaginal deliveries, making it a preferred option for PPH prevention in high - risk cases.


Keywords: Postpartum Hemorrhage (PPH), Oxytocin, Carbetocin, Vaginal Delivery, Uterotonics, Blood Loss Reduction, High - Risk Pregnancy, Hemoglobin Drop, PPH Prevention


Edition: Volume 13 Issue 12, December 2024


Pages: 743 - 746


DOI: https://www.doi.org/10.21275/SR241202010036



Make Sure to Disable the Pop-Up Blocker of Web Browser


Text copied to Clipboard!
Dr. Akanksha, Dr. Parul Prakash, Dr. Rupal Gandhi, "Comparison of Oxytocin versus Carbetocin in Vaginal Delivery - A Randomised Controlled Study", International Journal of Science and Research (IJSR), Volume 13 Issue 12, December 2024, pp. 743-746, https://www.ijsr.net/getabstract.php?paperid=SR241202010036, DOI: https://www.doi.org/10.21275/SR241202010036

Similar Articles

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Comparative Studies, Obstetrics and Gynecology, India, Volume 11 Issue 10, October 2022

Pages: 1048 - 1051

Comparative Study between Carbetocin Versus Oxytocin for the Prevention of Atonic Postpartum Hemorrhage after Repeated Elective Cesarean Sections

Dr. A. Himaja, Dr. Siva Jyothi, Dr. Sruthi

Share this Article

Downloads: 47 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2

Research Paper, Obstetrics and Gynecology, India, Volume 10 Issue 2, February 2021

Pages: 1367 - 1369

Study of Risk Factors of Post-Partum Hemorrhage and Its Outcome at Tertiary Care Center

Dr. Sunny Solanki, Dr. Ritu Bijarniya, Dr. Divya Mittal

Share this Article
Top