Synthesis and Characterization of 5-Substituted Hydantoins as Potential Antimicrobial Inhibitor: A Review Article

Gajanan B. Ingle, Dr. Sanjay V. Kolhe

Abstract: This work presents the synthesis, characterization and evaluation of a series of new multifunctional N-substituted hydantoin derivative for their antibacterial and antifungal activity. Elemental analysis, 1H NMR, IR and mass spectroscopy were used to confirm the newly synthesized compound structure. The antibacterial and antifungal properties of each synthesized molecule were examined. The examined compound showed significant to moderate antimicrobial activity against the tested Gram-positive, Gram-negative, and fungal strains. The antimicrobial activities were influenced by the structure and concentration of the tested compounds as well as the type of test microorganisms. The examined hydantoin derivatives seem as drug-like candidate for further evaluation of biological activities examined.

Keywords: Hydantoin, Drugs, Antimicrobial properties, Pharmacophores, Heterocycles