Investigating the Distribution of Actinobacteria spp in Gastric Adenocarcinoma Patients with Helicobacter Pylori

Ihab Mohamed Taher, Mohammed Hachim Nasser

Abstract: Background: Adenocarcinoma is the most common type of stomach cancer that arises from the epithelial glands of the stomach. Most gastric adenocarcinomas are diagnosed in advanced stages and therefore the mortality rate in them is high. Stomach cancer is the second most common cause of cancer death worldwide, accounting for more than one million deaths each year. Infection with H.pylori is a major predisposing factor for gastric adenocarcinoma. Infection with this bacterium causes chronic and persistent stomach inflammation by inducing the expression of inflammatory cytokines that play an important role in stomach cancer. In addition to host factors, H. pylori pathogenic factors increase the risk of gastric cancer, especially cagA, which is encoded by the cagA gene. The purpose of this research is to investigate the role of Actinobacteria infection in gastric adenocarcinoma in patients with Helicobacter pylori. Research method: In this study, in the patient group, there were 24 (75.0%) men and 8 (25.0%) women, and in the control group, there were 10 (50.0%) men and 10 (0.0 50 percent) of women were examined. In order to investigate Actinobacteria and Helicobacter pylori infections, RT-PCR method was used. Results: The obtained results showed that 81.3% of patients were positive for H.Pylori (Cag-A+) and 18.3% were negative for H.Pylori (Cag-A+). Therefore, most of the patients were positive for H. Pylori. Also, sick people were examined for the level of Actinobacteria. The obtained results showed that 37.5% of sick people are positive for Actinobacteria. Conclusion: Since most patients (81.3%) are positive for H. Pylori (Cag-A+), this result shows that H. Pylori plays an important role in the occurrence of gastric adenocarcinoma. Also, 37.5% of the studied patients are also positive for Actinobacteria, which shows that this bacterium can also play an important role in the progression of the disease.

Keywords: gastric adenocarcinoma, Helicobacter pylori, Actinobacteria