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Review Papers | Dentistry | India | Volume 13 Issue 1, January 2024
New Fangled Avatar of Neutrophils and its Role in Periodontitis
K. Malathi [4] | C. Hima Bindu Reddy [2] | Varshini S. [2] | Rachana Anagol | Rohit M.
Abstract: Periodontitis is associated with several factors, such as smoking, diabetes, age, and immune deficiency. Current studies support that periodontitis is initiated by periodontal bacteria, and neutrophils are the primary immune cells recruited to exert an antibacterial effect. There is a reciprocal interaction between the microbiota and the immune system which breeds a feed forward loop wherein each entity fortifies each other. The inflammation caused due to the microbiota creates a nutrient rich ambience for the microbes and the thriving microbe amplifies the inflammation causing progressive damage to the tissues. Neutrophils are myeloid leukocyte cells forming the initial fire wall between the microorganisms and the cells acting as executive phagocytes. Neutrophils were thought to be a part of acute conditions only, recent studies have started to reveal that they also play pivotal role in regulating adaptive immunity and perform other functions such as reverse transmigration, immunoregulation, angiogenesis and fibrogenesis. Therefore, preventing bacterial evasion might be a potential preventive action and opens up new therapeutic modalities for treatment of periodontitis This article elaborates on recruitment of neutrophils and its homeostasis, the antimicrobial mechanisms, evasion strategies of microbes against neutrophils and new developments related to it and its relation to periodontitis.
Keywords: neutrophils, periodontitis, transmigration, immunity, phagocytosis
Edition: Volume 13 Issue 1, January 2024,
Pages: 525 - 530