Comparison of Ultrasound Guided Intra - Articular Injection of Platelet Rich Plasma Versus High Molecular Weight Hyaluronic Acid in Improving Cartilage Thickness and Physical Functions in Patients with Primary Osteoarthritis of Knee: A Randomized Controlled Trial
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Comparative Studies | Physical Medicine and Rehabilitation | India | Volume 13 Issue 10, October 2024 | Popularity: 5 / 10


     

Comparison of Ultrasound Guided Intra - Articular Injection of Platelet Rich Plasma Versus High Molecular Weight Hyaluronic Acid in Improving Cartilage Thickness and Physical Functions in Patients with Primary Osteoarthritis of Knee: A Randomized Controlled Trial

Sumit Debnath, Romi Singh Nongmaithem, Dharshan Na, Sithara M, Yambem Hellena Devi, Jotin Yengkhom, Shahin Kannamthodi Erumbanottil


Abstract: Objective: To compare ultrasound - guided intraarticular injection of platelet - rich plasma versus high molecular weight hyaluronic acid in improving cartilage thickness and physical functions in patients with primary osteoarthritis of knee. Materials and Methods: A randomized control trial conducted in the department of Physical Medicine and Rehabilitation, Regional Institute of Medical Sciences, Imphal, Manipur, India with sample size of 60 patients diagnosed with primary osteoarthritis of the knee, 60 patients were randomized to receive either ultrasound - guided single - dose intraarticular injection of platelet - rich plasma (study group) or high molecular weight hyaluronic acid (control group), Visual analog scale (VAS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and femoral condylar cartilage thickness by musculoskeletal ultrasound imaging. Follow up at 12 weeks, 24 weeks, and 36 weeks. Results: Both groups showed significant statistical improvement in VAS pain and WOMAC scores at 12, 24, and 36 weeks, but with no significant difference between the groups (p>0.05). VAS score in PRP group was 5.8?0.924 at baseline and 1.8?0.664 at 36 weeks. VAS score in hyaluronic acid group at baseline was 6.0?0.946 and at 36 weeks was 2.0?0.639. WOMAC score in PRP group at baseline was 29.13?11.77 and at 36 weeks was 13.6?8.915. In hyaluronic acid group WOMAC improved from baseline (29.53?11.06) to 36 weeks (11.6?6.284). There was no change in femoral condylar cartilage thickness in either group till 36 weeks follow - up. Conclusions: Single - dose intraarticular injection of platelet - rich plasma improves physical function in primary osteoarthritis knee but does not increase femoral condylar cartilage thickness. No additional benefits compared to a single - dose intraarticular high molecular weight hyaluronic acid injection.


Keywords: Platelet - rich plasma (PRP), High molecular weight hyaluronic acid, HMWHA, Knee osteoarthritis, Femoral condylar cartilage thickness, Western Ontario and McMaster University Osteoarthritis Index, WOMAC


Edition: Volume 13 Issue 10, October 2024


Pages: 1055 - 1060


DOI: https://www.doi.org/10.21275/SR241014192132



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Sumit Debnath, Romi Singh Nongmaithem, Dharshan Na, Sithara M, Yambem Hellena Devi, Jotin Yengkhom, Shahin Kannamthodi Erumbanottil, "Comparison of Ultrasound Guided Intra - Articular Injection of Platelet Rich Plasma Versus High Molecular Weight Hyaluronic Acid in Improving Cartilage Thickness and Physical Functions in Patients with Primary Osteoarthritis of Knee: A Randomized Controlled Trial", International Journal of Science and Research (IJSR), Volume 13 Issue 10, October 2024, pp. 1055-1060, https://www.ijsr.net/getabstract.php?paperid=SR241014192132, DOI: https://www.doi.org/10.21275/SR241014192132