International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

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Research Paper | Cardiology Science | India | Volume 12 Issue 9, September 2023

Prospective Study to Evaluate the Effect of Optimal Medical Therapy on Iron Profile in Patients of Chronic Heart Failure in Tertiary Care Hospital in Kolkata

Dr. Mukesh Kumar Agrawal | Dr. Bappaditya Kumar [2] | Dr. Somnath Mukhopadhay [2]

Abstract: Introduction: Heart failure is considered a heterogeneous syndrome and is characterized by abnormalities in cardiac structure or function. In recent decades, our understanding of the heart failure syndrome has led to remarkable advances in terms of prevention, diagnosis and treatment possibilities. In recent years, iron deficiency has emerged as a newly recognized co-morbidity of chronic HF. Independently of anemia, iron deficiency occurs frequently in HF patients, contributing to cardiac and peripheral muscle dysfunction, and is a strong predictor of poor clinical outcome. Aims and objectives of the study: General Objectives: To evaluate the effect of optimal medical therapy in patients of chronic heart failure over iron profile in parallel with disease progression. Specific Objectives: To examine the relationship between iron deficiency and Functional status in patient with chronic Heart Failure. Materials and methods: Place of study: Department of Cardiology, Medical college, Kolkata. Study Population: All consecutive patients admitted with HF in Medical College Kolkata. Study Period: One year (after ethics committee clearance). Sample Size: A total of 101 subjects. Sample Design: Consecutive eligible. Study Design: Single centre prospective study. Results: It can be observed that with more advancement of age the progression of heart failure worsens and elderly are more prone to advanced heart failure. In our study the mean level of hemoglobin was 10.95 ?1.71 g/dl and it has gradually increased to mean level of 11.57 ?1.61 g/dL after the optimal medical therapy with iron supplementation across all the NHYA functional class and is statistically highly significant (p value <0.0001).The correlation of gender with heart failure in our case is not significant. In our study, it can be clearly observed that with the progression of advanced heart failure classes the mean level of iron, ferritin and transferrin is worsening or is very low. The relationship between serum ferritin levels and new onset heart failure appears to be linear. The group treated with iron demonstrated a significant improvement in renal function and NYHA class.

Keywords: Heart failure, Iron deficiency, Optimal Medical Therapy, Functional Status

Edition: Volume 12 Issue 9, September 2023,

Pages: 1372 - 1382

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