Intranasal Malignantmelanoma: Pathogenesis Epidemiology and Clinical Insight

Lakshita Rohilla, Karandeep Singh, Abhijit Garg

Abstract: Malignant melanoma in nasal cavity and paranasal sinuses is a rare and aggressive tumor, comprising a small percentage of all melanomas. This article explores the pathogenesis and epidemiology of this condition, shedding light on its distinct characteristics from cutaneous melanoma. Despite understanding, the 5 year survival rate remains low emphasizing the need for effective diagnosis and treatment strategies. The case report of a 65 year old male with nasal cavity melanoma highlights the clinical presentation and diagnostic challenge associated with this malignancy. The article emphasizes the importance of thorough evaluation including fibroscopic examination and imaging techniques in achieving a conclusive diagnosis. Surgical intervention remains the primary treatment modality with chemotherapy and radiotherapy as adjuncts.

Keywords: Primary mucosal melanoma, Nasal cavity, Pathogenesis, Epidemiology, Clinical presentation, Treatment modalities