Squamous Cell Carcinoma of Colon: A Case Series of a Rare Histology

Era Sankhyayan, Naina Negi

Abstract: Squamous cell carcinoma of colon is a very rare histological finding with incidence of 0.1-0.25/1000 colorectal carcinomas seen most commonly in recto - sigmoid region. Several theories have been postulated to explain the pathophysiology of the disease e. g, association with a chronic inflammatory process, origin from colo - cutaneous fistulas, parasitic infection, differentiation of multipotent stem cells to squamous cell dysplasia and subsequently carcinoma. As per limited literature available, Surgery remains mainstay of treatment with adjuvant chemotherapy based on platinum analogues and 5FU. SCC colon is considered to be more aggressive carrying worse prognosis than adenocarcinoma. We present a case series of 3 patients, out of which two presented with primary SCC of ascending colon treated with cisplatin - 5FU regimen and 1 presented with adeno - squamous carcinoma of rectum treated with CAPOX based chemotherapy.

Keywords: Squamous cell carcinoma, colorectal carcinomas, chemotherapy, adenosquamous carcinoma