Early Diagnosis of HIV-1 to Newborns Born from Mothers on Antiretroviral Treatment in Chad: A Prospective Study Using Real-Time PCR in Chad

Fabienne Byakzabo Chinka, Hassan Mahamat Ali, Bakarnga-Via Issakou, Brahim Boy Otchom, Foumsou Lhagadang

Abstract: Introduction: AIDS is the fourth leading cause of death worldwide. The majority of those infected are young adults, and young women are a particularly vulnerable group. In HIV-1-infected pregnant women, biological monitoring is essential for the management of HIV-1 infection and the prevention of mother-to-child transmission. Diagnosis of HIV infection by PCR makes it possible to identify infected children born to HIV-positive mothers and to start early treatment to avoid the risk of mortality. Methodology: The aim of our study was to use PCR to diagnose children born to HIV-1 mothers undergoing antiretroviral treatment in Chad. We carried out a prospective descriptive cross-sectional study from June 2021 to January 2023 on 185 women on antiretroviral treatment. For this study, we used the molecular technique with an HIV-1 expert gene device. Results: 185 pregnant women on ARV treatment and 183 newborns were registered. In this sample, mothers in the 20-30 age group were the most represented, with a frequency of 53.3%. Married women were in the majority with a proportion of 71.4%, and 27.6% of women had a secondary education. Analysis of the type of ARV treatment showed that 74.32% were on dolutegravir. The rate of TCD4 lymphocytes below 200 cells/mm3 at initiation was 16.8%. By the sixth month, a remarkable immune recovery had been achieved, with 96.2% of the TCD4 lymphocyte count greater than or equal to 500 cells/mm3 up to M12. We recorded 68.24% of subjects with undetectable viral load results (

Keywords: HIV, mothers, Newborns, Antiretroviral, Chad

How to Cite?: Fabienne Byakzabo Chinka, Hassan Mahamat Ali, Bakarnga-Via Issakou, Brahim Boy Otchom, Foumsou Lhagadang, "Early Diagnosis of HIV-1 to Newborns Born from Mothers on Antiretroviral Treatment in Chad: A Prospective Study Using Real-Time PCR in Chad", Volume 12 Issue 9, September 2023, International Journal of Science and Research (IJSR), Pages: 1089-1093, https://www.ijsr.net/getabstract.php?paperid=SR23825001706, DOI: https://dx.doi.org/10.21275/SR23825001706

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