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Research Paper | Medical Science | India | Volume 12 Issue 8, August 2023
Differentiating Undifferentiated Fever: Comparative Analysis of Blood Count Profile and Clinical Features in Tropical Hospital
Dr. Ajmal Nazir N | Dr. Jayakumar J
Abstract: Aim: A study on complete blood count profile and clinical features in undifferentiated fever of short duration in our Hospital. Objectives: 1. To knows and compares complete blood count profile (TC, DC, Platelet and Hemoglobin) and clinical findings between undifferentiated fever of short duration commonly seen in our hospital. MATERIALS AND Method: In our Hospital based cross sectional study of 2 year duration in all hospitalized patients with fever duration less than 21 days with no localizing signs and as per the inclusion criteria were considered and detailed history, clinical examination and CBC was done for the patients included in the study as per the inclusion criteria. Among those, 80 malaria cases (thick and thin smear +), 68 Dengue fever (IgM ELISA+), 20 Enteric fever (blood culture +), 20 Leptospirosis (IgM ELISA positive) and 12 Rickettsial fever (scrub typhus) by Weil felix initially and diagnosis is confirmed by IgM ELISA were segregated from the group to make a sample size of 200. Data analysis was done by univariable analysis and managed on Microsoft excel. Characteristics of each disease group were compared with those of the remaining group. p< 0.05 will be considered as significant. . Results of multivariable analyses were presented as the odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: In our study, out of 200 cases of AUF 68.5% patients were male. Of these 200 cases Malaria (40%) and dengue fever (34%) were the most common cause of acute undifferentiated fever (AUF), followed by leptospirosis (10%), Enteric fever (10%) and scrub typhus (6%). Among 80 cases of malaria 70 (87.5%) presented with chills and rigor and 52 (65%) patients were having splenomegaly clinically. Among the 68 cases of dengue fever 35 patients (51.5%) presented with retro - orbital pain, 36 patients (52%) with joint pain. Clinically no patients were having splenomegaly and was a significant finding (p value - < 0.001) in dengue fever group when compared with the other AUF group. Leukopenia was seen in 43 patients (65.2%) and thrombocytopenia in all 67 patients (98.5%) was noted among the dengue fever group. Among the 20 cases of enteric fever 17 patients (85%) presented with diarrhea and 16 patients (80%) were having splenomegaly. Eosinopenia was seen in 14 patients (70%) which was a significant finding when compared with the other AUF group (p value of < 0.001). Among the 20 cases of leptospirosis 17 patient (80%) was having myalgia, 13 patients (65%) was having jaundice and 16 patients (80%) was having muscle tenderness. Clinically hepatomegaly was seen in 13 patients (65%). Leukocytosis was seen in 14 patient (70%) with a significant p - value of <0.001. Among the 12 cases of Rickettsial fever (scrub typhus) 8 (66.7%) patient were having black eschar and lymphadenopathy were noted in 8 patient (66.7%) which was also having a significant p - value when compared with the other AUF group. Leukocytosis was also noted in 11 patients (91.7%) which is significant when compared with the other AUF group. Conclusion: In a resource - limited setting and disease burden areas, simple complete blood count profile and detailed clinical examination will be having significant utility in differentiating the five common aetiology of undifferentiated fever in tropical.
Keywords: Complete blood count, undifferentiated fever, Clinical features, tropical hospital, comparative analysis
Edition: Volume 12 Issue 8, August 2023,
Pages: 2106 - 2112