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Research Paper | Biochemistry | India | Volume 12 Issue 8, August 2023
Correlation of Leptin - Adiponectin Ratio with HDL and hsCRP in Obese Postmenopausal Women: Implications for Metabolic Health
Dr. Vanita Sonagara | Dr. Ranjana Mathur [2]
Abstract: Introduction: Menopause is a significant issue for public health among women, since it is linked to an increase in both visceral and total body fat. Compared to premenopausal women, postmenopausal women are more likely to be obese. Adverse metabolic changes like insulin resistance, a propensity to develop type 2 diabetes, and dyslipidaemia, which is marked by high triglyceride levels, low HDL cholesterol levels. Adiponectin exhibits a strong potential to improve insulin sensitivity and prevent the onset of diabetes, whereas leptin is positively connected with obesity and insulin resistance. In present study, we are trying to find out correlation of serum leptin, adiponectin ratio with serum HDL, and hsCRPin obese nondiabetic and diabetic postmenopausal women. Material and methods: In this study, 150 obese nondiabetic (Group - I) and 150 obese diabetic (Group - II) postmenopausal women were recruited. Blood samples were collected and were processed for biochemical investigations by standard protocol using commercially available reagents and kits on fully automatic chemistry analyzer, ELISA and Chemiluminescence analyzer. Results: The mean age of Group - I and Group - II postmenopausal subjects was 52.7?3.39 years and 53.03?3.29 years respectively. Mean Serum Cholesterol of the Group - I postmenopausal and Group - II postmenopausal subjects was 210.96?15.13 and 251.8?19.62 mg/dL with statistically significant difference (p<0.0001). A highly significant decrease was observed in the serum HDL of Group - II postmenopausal subjects (p<0.0001). A non significant increase was observed in the serum hSCRP of Group - II postmenopausal subjects (p=0.019). We found negative correlation between L: A ratio and serum HDL, and positive correlation between L: A ratio and serum hsCRP. Conclusion: According to our study, diabetic women's adiponectin levels are lower than those of nondiabetic women. Our findings have clinical implications and point to the L/A ratio as a potential surrogate diagnostic for the metabolic syndrome.
Keywords: Diabetes, Dyslipidemia, Insulin Resistance, Obesity, Postmenopausal Women
Edition: Volume 12 Issue 8, August 2023,
Pages: 2329 - 2332