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Comparative Studies | Medical Science | Volume 12 Issue 8, August 2023 | Pages: 1037 - 1042 | India
Comparative Study: Impact of Propofol and Ketamine Pretreatment on Succinylcholine - Induced Myalgia
Abstract: Background: Succinylcholine is still considered to be the muscle relaxant of choice for performing endotracheal intubation during general anaesthesia. Most common side effect after succinylcholine administration is postoperative myalgia which can cause significant discomfort in patients. Pretreatment with various pharmacological agents have been tried to decrease incidence of myalgia caused after the administration of Succinylcholine with varying success. We conducted the study to compare the effect of pretreatment with Propofol and Ketamine on incidence & severity of Succinylcholine induced postoperative myalgia. Methodology: After obtaining approval from the institutional ethics committee; a prospective, randomized, double blind, study was conducted in ASA Grade I, II male & female patients between age group 18 to 65 years undergoing surgeries of 0.05). We observed that the incidence & severity of fasciculation was higher in Ketamine group compared to other 2 groups with Propofol group showing least values. The incidence of post operative myalgia was significantly less (10%) at 24 hours in both Propofol and Ketamine group as compared to Normal saline group (50%) (p=0.006). None of the patients complained of moderate or severe grade myalgia in any group. There were no statistically significant changes in heart rate between Propofol and Ketamine groups. Normal saline group showed more increase in heart rate compared to other groups (p
Keywords: Fasciculations, Ketamine, Myalgia, Propofol, Succinylcholine
How to Cite?: Dr. Aakansha Bharat, Dr. Vasanti Sasturkar, Dr. Tulika Newale, "Comparative Study: Impact of Propofol and Ketamine Pretreatment on Succinylcholine - Induced Myalgia", Volume 12 Issue 8, August 2023, International Journal of Science and Research (IJSR), Pages: 1037-1042, https://www.ijsr.net/getabstract.php?paperid=SR23805083313, DOI: https://dx.doi.org/10.21275/SR23805083313