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Research Paper | Pediatrics | India | Volume 12 Issue 8, August 2023
Assessing Liver Function in Beta-Thalassemia Patients: Exploring Blood Transfusion-Related Complications
Dr. Pallavi Kharde | Dr. Sudhir Sarawade
Abstract: Aim and objective: To find out the proportion of transfusion reaction symptoms of beta-thalassemia in paediatric age group patients and to estimate the biochemical parameters of liver functions and correlate them with serum ferritin levels. Material and method: The present cross-sectional study was conducted on 120 children with known beta thalassemia aged between 2-12 years on repeated blood transfusion. A thorough clinical examination with particular importance on the presence of pallor, jaundice, and signs of thalassemic features was done. An abdominal examination was done to rule out hepatosplenomegaly. Blood samples were collected for appropriate investigations including serum ferritin level, transferrin saturation, and liver function test. Results: In this study, 27.5% and 72.5% of children belonged to the 2-5 years and 6-12 years age category respectively. The majority of study subjects were male (65.33%). The incidence of jaundice, ascites, and hepatomegaly was found to be 90.83%, 36.67%, and 100% respectively. The incidence of jaundice, ascites, and hepatomegaly are more common in older age children. A significant positive correlation was found between serum ferritin and total bilirubin, direct bilirubin, and SGPT (P<0.05). Conclusion: In the present study, there was a positive significant correlation between serum ferritin and total bilirubin, direct bilirubin, and SGPT. Thus, as serum ferritin increases there is an increase in liver function parameters and enzymes and there will be more derangement in liver function probably because of an iron overload condition.
Keywords: Beta-thalassemia major, Iron overload, Organ dysfunction, viral hepatitis, Liver enzymes
Edition: Volume 12 Issue 8, August 2023,
Pages: 758 - 761