Randomised Double Blind Study for Comparison of Dexmedetomidine V/S Midazolam for Reduction of Incidence of Delirium Post Cardiac Surgery

Dr Ajay Sharma, Dr Reema Meena

Abstract: Background: Delirium is a neurobehavioral syndrome caused by the transient disruption of normal neuronal activity secondary to systemic disturbances. Objective: To Compare dexmedetomidine VS midzolam for reduction of incidence of post valvular cardiac surgery delirium. Methods: Patients underwent elective cardiac surgery with a standardrized intraoperative anesthesia protocol, followed by random assignment to one of two postoperative sedation protocols: dexmedetomidine, or midazolam. Results: Dexmedetomidine group (1/30) observed lesser incidence of delirium in comparison to midazolam group (12/30). Conclusion: Dexmedetomidine is a better drug to decrease the incidence of delirium post cardiac surgery over midazolam, with more haemodynamic stability and early extubation time.

Keywords: Delirium, neurobehavioral syndrome, transisent disruption, neuronal activity