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Short Communication | Pathology | India | Volume 12 Issue 7, July 2023

Being a Mole Spy: A Resilient Job (An Interesting Case Report)

Raghav Kapoor ^[3] | Shubham Varshney ^[2] | Adarsh Sanikop ^[2] | Aiusee Pooja ^[2]

Abstract: Context: Complicated Pigmented lesions of skin has always been a pathologists? nightmare. Distinguishing benign nevi from malignant melanoma using current histo - pathological criteria may be very challenging; large Congenital melanocytic Nevus (CMN) have a 2% to 42% risk of malignant transformation, with a 6% to 14% life - time risk of malignant melanoma. Case Report: We hereby present a case of 21 - year - old female patient admitted to our hospital with a mole on natal cleft area which had increased in size since last one year. Surgical excision was done and sent for Histopathological examination. Routine H&E showed a melanocytic lesion all over the dermis with heavy pigmentation, however, the epidermis appeared uninvolved. Bleach H&E along with IHC was performed for a definitive diagnosis of Congenital melanocytic nevus (CMN). Discussion & Conclusion: Congenital melanocytic nevi (CMN) are present at birth in 1% to 2% of newborns. Distinguishing benign nevi or Proliferative nevus (PN) from malignant melanoma is one the most difficult areas in dermatopathology and ancillary techniques should be used for confirmation of diagnosis. Ancillary techniques-Immunohistochemistry (IHC), In - Situ Hybridization (ISH) and Molecular & Genetic analysis provides a definitive diagnosis.

Keywords: Congenital melanocytic Nevus (CMN), Melanoma, Proliferative Nevus (PN) Immunohistochemistry (IHC)

Edition: Volume 12 Issue 7, July 2023,

Pages: 883 - 886