To Evaluate the Levels of Antioxidants Enzymes in Albino Rat Liver Tissue by Injecting Doxorubicin and Antioxidants Separately and in Combination

B. Vijayudu, M. Ravi Naik, K. Kalindhar Basha, M. Jaya Chandrudu, A. Venkata Mohan Naidu, P. Ramesh Kumar

Abstract: Doxorubicin is a anticancer drug, it is used in treatment of cancer through chaemotherapy, its effect mainly on cancer cells and also this produce some side effects. for reducing the adverse effects i was used some antioxidants with Dox combination and individually. In this study i was used in 20 mg/kg wt of Doxorubicin and 80 mg/kg wt of Vitamin E, 40 IU/kg wt of Vitamin A individually and in combination over 10weeks (weekly-Doses) on Albino rat Liver. Some antioxidant enzymes such as Superoxide Dismutase, Catalyse, Glutathione Peroxidase, Glutathione Reducatase, Glutathione-S-Transferase levels were estimated in the liver tissue of albino rat. The data of these enzymes I will show in result table from this result. It is reported that the antioxidants like Vitamin E, K reduce the Doxorubicin altered enzyme levels. It is used for cancer studies for better understanding.

Keywords: Liver Tissue, Doxorubicin, Antioxidant Enzymes, Vitamin E, and Vitamin A