International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Zoology | India | Volume 12 Issue 7, July 2023


To Evaluate the Levels of Antioxidants Enzymes in Albino Rat Liver Tissue by Injecting Doxorubicin and Antioxidants Separately and in Combination

B. Vijayudu | M. Ravi Naik | K. Kalindhar Basha | M. Jaya Chandrudu | A. Venkata Mohan Naidu | P. Ramesh Kumar


Abstract: Doxorubicin is a anticancer drug, it is used in treatment of cancer through chaemotherapy, its effect mainly on cancer cells and also this produce some side effects. for reducing the adverse effects i was used some antioxidants with Dox combination and individually. In this study i was used in 20 mg/kg wt of Doxorubicin and 80 mg/kg wt of Vitamin E, 40 IU/kg wt of Vitamin A individually and in combination over 10weeks (weekly-Doses) on Albino rat Liver. Some antioxidant enzymes such as Superoxide Dismutase, Catalyse, Glutathione Peroxidase, Glutathione Reducatase, Glutathione-S-Transferase levels were estimated in the liver tissue of albino rat. The data of these enzymes I will show in result table from this result. It is reported that the antioxidants like Vitamin E, K reduce the Doxorubicin altered enzyme levels. It is used for cancer studies for better understanding.


Keywords: Liver Tissue, Doxorubicin, Antioxidant Enzymes, Vitamin E, and Vitamin A


Edition: Volume 12 Issue 7, July 2023,


Pages: 866 - 872


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