A Comparative Study between the Efficacy of Lithium with Sodium Valproate Combination Therapy and Lithium with Carbamazepine Combination Therapy in Patients with Euthymic Bipolar Disorder
Abstract: Introduction: Treatment of bipolar disorder (BD) usually requires drug combinations. Lithium, sodium valproate and carbamazepine are each recommended as a monotherapy for preventing relapses in patients with bipolar disorders and are sometimes used in various combinations. However, Li/SVP and Li/CBZ combination have never been compared rigorously. Materials and methods: 70 patients aged 20 - 55 years diagnosed as bipolar disorder as per ICD 10 and euthymic for atleast 6 months - (HAM - D ?8, YMRS?6) who were on Lithium and sodium valproate combination therapy were chosen as group Li/SVP and on Lithium and carbamazepine combination therapy were chosen as group Li/CBZ. Functioning, quality of life, neurocognition and safety were assessed and compared between both groups. Results: Patients on Lithium and sodium valproate combination therapy had better GAF and WHOQOL - BREF score with statistically significant results (p
Keywords: Bipolar disorder, Sodium valproate, Lithium, Carbamazepine
How to Cite?: Rajveer Singh Nirwan, Saravjot Kaur Sandhu, Rajendrakumar Katte, "A Comparative Study between the Efficacy of Lithium with Sodium Valproate Combination Therapy and Lithium with Carbamazepine Combination Therapy in Patients with Euthymic Bipolar Disorder", Volume 12 Issue 6, June 2023, International Journal of Science and Research (IJSR), Pages: 1725-1730, https://www.ijsr.net/getabstract.php?paperid=SR23616114833, DOI: https://dx.doi.org/10.21275/SR23616114833