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Research Paper | Pharmaceutical Science | India | Volume 12 Issue 6, June 2023

Formulation and Evaluation of Mesoporous Silica Nanoparticles to Treat Cancer Induced Emesis

Venkatesh Dinnekere Puttegowda | C S Lakshmeesha

Abstract: The present work is aimed to formulate and characterize the Palonosetron HCl loaded mesoporous silica nanoparticles to treat chemotherapy induced emesis. This Palanosetron loaded MSNs were prepared by using solvent - based method (solvent immersion & DiSuplo method) at different weight ratios, speed (rpm), and time (h). The preliminary tests such as identification & solubility of drug studied by using UV & FTIR, various physicochemical characterization of mesoporous silica particles and Palanosetron loaded MCM - 41 MSNs (Mesoporous nanoparticles) F1 - F6 were evaluated by using Particle size, SEM & BET analysis. In vitro drug release studied from optimized (DOE) formulations using dissolution medium hydrochloric acid solution (pH 1.2) and phosphate buffer (pH 6.8). MCM - 41 - Palanosetron (F1) were determined to have the highest drug loading efficiency, 97.0?2.19%. The BET surface area of MCM - 41 were found to have 999.438 to 1472.227 m2/g, pore volumes of 1.073 to 1.141 cc/g, and average pore sizes of 2.495 to 4.827 nm. SEM results of F1 revealed that, particle morphology as a uniform spherical like structure of size ? 450 nm to ? 570 nm at 4.00KX & 3.00KX magnification. The drug loaded MSNs were stable at 40?2?C/75?5% RH, throughout one month period. The optimized formulations revealed that palanosetron loaded MCM - 41 mesoporous particles are best suited for emetic therapy in case of Chemotherapy.

Keywords: Mesoporous silica nanoparticles (MSNs), Emesis, MCM - 41, Palanosetron

Edition: Volume 12 Issue 6, June 2023,

Pages: 944 - 951