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Research Paper | Medical Science | India | Volume 12 Issue 6, June 2023
A Prospective Observational Study of Relationship between the C-Reactive Protein-to-Albumin Ratio and Uric Acid-to-Albumin Ratio to the Extent of CAD in Patients Presenting with Acute Coronary Syndrome in a Tertiary Care Centre
Dr. Soorya Narayanan | Dr. N. Swaminathan 
Abstract: Background: This study aimed to investigate the predictive value of the newly defined C-reactive protein (CRP)-toalbumin ratio (CAR) and Uric acids albumin ratio (UAR) in determining the extent and severity of coronary artery disease (CAD) in comparison with the other inflammatory markers such as neutrophil-to lymphocyte ratio (NLR) in patients with Acute coronary syndrome (ACS). Patients and methods: This study is prospectively designed and includes 100 patients with ACS. The study cohort was subdivided into two groups according to Synergy between Percutaneous Coronary Intervention with Taxus and cardiac surgery score (SS) as low (< 22) and intermediate-high (?22). Complete blood counts, serum CRP, and serum albumin were obtained at admission. The CAR, UAR and NLR values of all patients were calculated. Then, we evaluated the relationship of CAR, UAR and NLR with the CAD extent and severity. Results: CAR, UAR and NLR were moderately correlated with SS, but PLR showed weak correlation with SS. According to multivariate analysis models, CAR, NLR, and left ventricular ejection fraction were found to be independent predictors of CAD severity (P < 0.05. A CAR more than 17 and UAR of more than 0.16 predicted an intermediate-high SS. Conclusion: Novel inflammatory marker CAR and UAR can be used as a reliable marker in prediction of CAD severity in patients with ACS.
Keywords: C-reactive protein (CRP)-to albumin ratio (CAR), Uric acids albumin ratio (UAR) neutrophil-to lymphocyte ratio (NLR) Acute coronary syndrome (ACS)
Edition: Volume 12 Issue 6, June 2023,
Pages: 523 - 525