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Research Paper | Anaesthesiology | India | Volume 12 Issue 5, May 2023

A Randomised Controlled Trial of 0.5 Mcg / Kg and 1 Mcg/Kg of Dexmedetomidine on Attenuation of Haemodynamic Response to Extubation among Patients Undergoing Elective Surgeries

Renuka Jinger | Fareed Ahmed ^[4] | Mamta ^[59] | Shailaja ^[15]

Abstract: Background: Endotracheal extubation elicit a strong sympathoadrenal response with potentially fatal implications in individuals with cardiovascular and cerebrovascular illnesses. To counteract this reaction, a variety of pharmacological treatments have been used. Aim: To compare the clinical effectiveness of two different doses of dexmedetomidine (0.5?g/kg versus 1?g/kg) for attenuation of cardiovascular response to extubation in patients undergoing major surgeries. Material and Method: Study Design: This was a single centre, hospital (in - patient) based, parallel - group, 1: 1, double - blind, active - controlled, randomised control study conducted by enrolling a total of 120 participants (60 participants in each group). The haemodynamic parameters: Heart Rate, Blood Pressure and side effects were measured in both the groups. Results: The mean ?time for extubation? among the participants in the 0.5?g/kg and 1?g/kg group were 491 and 542 seconds, respectively. The pressor reflex was more effectively attenuated among the participants given 1 ?g/kg in comparison to participants given 0.5?g/kg of Dexmedetomidine. The incidence of side effects viz. sedation, hypotension and bradycardia were significantly higher among the participants given 1 ?g/kg of Dexmedetomidine. Conclusion: Dexmedetomidine in dose of 1?g/kg attenuate the pressor reflex more effectively. High dosage of Dexmedetomidine was also associated with higher incidence of side effects.

Keywords: Extubation, Dexmedetomidine

Edition: Volume 12 Issue 5, May 2023,

Pages: 2370 - 2376