Correlation of Inflammatory Marker and Vitamin D Level with Carotid Intima Media Thickening in Pre- Diabetes

Dr. Nutan Agarwal, Dr. Diksha Singh, Dr. Rahul Khokher, Dr. Pallavi Agarwal

Abstract: Introduction: Inflammatory markers (ESR, CRP, IL - 6 and NLR) are increased as the CIMT increases suggesting the role of inflammatory markers in pathogenesis of atherosclerosis in prediabetics. Aims and Objectives: To find the correlation of inflammatory markers, vitamin D levels with CIMT in prediabetes. Methods: The study type is cross sectional study. The work was conducted in Department of Medicine, M. L. B. Medical College, Jhansi. A sample size of 200 patients attending Medicine OPD/IPD and Diabetic OPD were selected as per criteria. Results: In our study 78 out of 100 prediabetics had low Vitamin D level, 66 had raised CRP level, 68 had raised ESR level, 68 had raised IL - 6 level, 67 had Vitamin D < 30 and CIMT > 0.88. Conclusion: Evaluation of inflammatory markers, vitamin D level and measurement of CIMT in pre diabetics can serve as an early marker of atherosclerosis, allowing physicians to plan early interventions to decrease future cardiovascular disease risk.

Keywords: prediabetics, inflammatory markers, CIMT, Vitamin D