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Review Papers | Biomedical Sciences | Indonesia | Volume 12 Issue 5, May 2023
Melatonin as a Marker of Aging Process
Abstract: Skin aging is a change in the structure of the skin which is a consequence of increasing age. Exposure to ultraviolet (UV) light, which can induce the formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) thereby damaging cells, can trigger aging. The appearance of signs of skin aging can interfere with appearance so many people start using skin care products. Human skin cells are known to synthesize and possess several types of melatonin receptors. This study aims to determine melatonin as a marker of the aging process. This research method is a systematic literature review (SLR) on journal papers published from 2014-2021. The results show that aging is associated with increased free radicals and decreased tissue antioxidant capacity and that exogenous melatonin plays a protective role in aging through its action on free radicals. The production of endogenous intracutaneous melatonin, together with topically applied exogenous melatonin and its metabolites, represent the two most powerful defense systems against external damage to the skin. Melatonin is in an optimal position to scavenge radicals and reduce levels of oxidative damage. Given the "free radical aging theory", including all its iterations, high levels of melatonin in mitochondria are expected to protect against age-related decline in organisms. Also, there are many age-related diseases, as a contributing factor, to free radical damage. In women with aging skin, Melatonin-based creams significantly increase skin tonicity and skin hydration with a significant reduction in skin roughness, supporting the antiaging effect of the skin.
Keywords: Melatonin, Aging Process, Free Radicals
Edition: Volume 12 Issue 5, May 2023,
Pages: 1391 - 1394