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Comparative Studies | Gynaecology | India | Volume 12 Issue 5, May 2023
Does the Incorporation of Dual Trigger Improve IVF Outcome When Compared to HCG Trigger in IVF / ICSI Cycles?
Abstract: Background: Utilization of HCG alone for stimulating oocyte growth was associated with many undesired effects like affecting endometrial receptivity and associated with OHSS. Dual trigger involves administering both GnRH agonists and HCG together. Objectives: To compare the effect of dual trigger with HCG trigger in IVF outcome and to compare the outcome in case of poor responder, normal responder and hyper responders with regard to dual and HCG triggers. Material and methods: The present study was retrospective observational study carried out among sub fertile women who underwent IVF/ICSI cycles in the department of institute of reproductive medicine between 2018 and 2021. The sample size was calculated to be 120 in each group. Data collection was made using secondary data. The data analysis was done using SPSS, independent samples t test and chi square test were applied. Results: Baseline characteristics were found to be similar between the groups. The mean number of expected follicles in the dual trigger group was 10.46 ? 5.91 and that of the HCG trigger group was 9.07 ? 1.51. The mean number of oocytes retrieved in the dual trigger group was 12.03 ? 7.31 and that of the HCG trigger group was 10.08 ? 5.48. Number of oocytes retrieved was significantly more in the dual trigger group than in the HCG group. All other parameters with regard to stimulation was similar between the groups. Sub group analysis revealed the parameters to be comparable between the groups. Implantation rate was similar between the groups while clinical pregnancy and live birth rates were more in HCG than in dual trigger group. Conclusion: Dual trigger resulted in a greater number of oocytes retrieved than the HCG trigger. The clinical pregnancy rate and live birth rate were more in HCG trigger than in the dual trigger.
Keywords: HCG trigger, Dual trigger, GnRH agonists, oocytes, clinical pregnancy rate, live births, implantation rates
Edition: Volume 12 Issue 5, May 2023,
Pages: 1120 - 1125