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Research Paper | Medical Science | India | Volume 12 Issue 4, April 2023
Profile of Acute Kidney Injury in Children Hospitalized with Nephrotic Syndrome: An Observational Study from Bihar, India
Abstract: The study aimed to assess the characteristics of AKI in children hospitalized with nephrotic syndrome. The present study was conducted on n=271 children aged <15 years admitted due to nephrotic syndrome. Aninformation regarding demography, clinical and physical, haematological examination were recorded. The responsiveness of the disease to first line therapy of oral steroids was assessed and categorized. Total duration of hospital stay was also recorded. Among n=271, n=66 patients were diagnosed with AKI. The prevalence of AKI was found to be 24.35%. The age of onset of AKI was 3 - 5 years in 31.25% of children followed by it was <3 years, >10 years, and 5 - 10 years in 27.54%, 25%, and 16.33% of children respectively suggesting no association (P=0.1177). AKI was associated with response to steroid, albumin, cholesterol, hypertension, and urine infection (P<0.05). The duration of hospital stay in AKI patients was significantly more than their counterparts (11.09?5.04 days vs 6.89?2.96 days, P<0.00001). Response to steroids, use of nephrotoxic medications, hypertension, urine infection, increased total cholesterol level, and low serum albumin concentration were the main risk factors of AKI.
Keywords: Acute kidney injury, childhood nephrotic syndrome, nephrotic syndrome, risk factors
Edition: Volume 12 Issue 4, April 2023,
Pages: 628 - 631