International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 2 | Views: 74 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Review Papers | Pharmacy | India | Volume 12 Issue 4, April 2023 | Rating: 4.5 / 10


Anti Cancer Activity of Naturally Occurring Heterocyclic Compound

Shafia Sultana | Pilli Archana | Dr. M. Vijaya Bhargavi [2]


Abstract: Indole compounds present in cruciferous vegetables have powerful anti-cancer capabilities. Indole-3-carbinol (I3C) and its dimeric form, 3, 3'-diindolylmethane (DIM), have been shown to block a number of cellular signaling pathways, including the PI3K/Akt/mTOR signaling pathway. These chemicals can block angiogenesis, overcome drug resistance, invasion, and change the phenotype of the epithelial-to-mesenchymal transition (EMT). It is becoming known that the PI3K/Akt/mTOR and NF-?b signaling pathways play an important role in EMT and control novel miRNAs. It has been examined how parental I3C and DIM, as well as their analogues and derivatives, regulate PI3K/Akt/mTOR/NF-B signaling.


Keywords: indole-3-carbinol, epithelial-to-mesenchymal transition, angiogenesis, cruciferous vegetables


Edition: Volume 12 Issue 4, April 2023,


Pages: 195 - 200


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