Anti Cancer Activity of Naturally Occurring Heterocyclic Compound

Shafia Sultana, Pilli Archana, Dr. M. Vijaya Bhargavi

Abstract: Indole compounds present in cruciferous vegetables have powerful anti-cancer capabilities. Indole-3-carbinol (I3C) and its dimeric form, 3, 3'-diindolylmethane (DIM), have been shown to block a number of cellular signaling pathways, including the PI3K/Akt/mTOR signaling pathway. These chemicals can block angiogenesis, overcome drug resistance, invasion, and change the phenotype of the epithelial-to-mesenchymal transition (EMT). It is becoming known that the PI3K/Akt/mTOR and NF-?b signaling pathways play an important role in EMT and control novel miRNAs. It has been examined how parental I3C and DIM, as well as their analogues and derivatives, regulate PI3K/Akt/mTOR/NF-B signaling.

Keywords: indole-3-carbinol, epithelial-to-mesenchymal transition, angiogenesis, cruciferous vegetables

How to Cite?: Shafia Sultana, Pilli Archana, Dr. M. Vijaya Bhargavi, "Anti Cancer Activity of Naturally Occurring Heterocyclic Compound", Volume 12 Issue 4, April 2023, International Journal of Science and Research (IJSR), Pages: 195-200, https://www.ijsr.net/getabstract.php?paperid=SR23330111844, DOI: https://dx.doi.org/10.21275/SR23330111844