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Comparative Studies | Anaesthesiology | India | Volume 12 Issue 3, March 2023

A Comparative Study of Effectiveness of Intravenous Lignocaine versus Lignocaine Nebulization on Stress Response to Laryngoscopy and Endotracheal Intubation

Dr. Nukala Dinesh | Dr. Boina Venkatasaikumar | Dr. Satish Kumar Vatturi | Dr. Zainab N Attar

Abstract: Background and objective: To evaluate the effectiveness of intravenous Lignocaine versus lignocaine nebulization on stress response to laryngoscopy and tracheal intubation in patients undergoing surgery under general anaesthesia. Methods and materials: This study was conducted in 80 patients of ASA grade I of both sexes in the age group of 18 - 60 years who were scheduled for various elective surgeries under General anaesthesia. They were randomly allocated into 2 groups. Patients in group N were given nebulization with 2% Lignocaine at a dose of 2mg/kg using nebulizer mask, 10 mins before induction of anaesthesia whereas patients in group I will receive 2%Lignocaine at a dose of 2mg/kg, 90 secs before intubation. Results: Changes in vital parameters like HR, MAP seen after the induction of anaesthesia and blunting of pressure responses were clearly observed. In I group when lidocaine 2% concentration 2 mg\kg was used can effectively reduce the stress and pressure response to endotracheal intubation. The hemodynamic changes were effectively stabilized in the intravenous group when compared to the nebulization group. In N group when lignocaine 2% concentration 2 mg\kg used to decrease stress and pressure response was not as effective as intravenous group. Conclusion: Proper nebulization and the use of a higher concentration of drug could have resulted in better hemodynamic stabilization performance. By administrating lidocaine in intravenous route and nebulization route can able to reduce the stress and pressure response to laryngoscopy and endotracheal intubation. In our study, early return of hemodynamic parameters to baseline values was observed in the intravenous group compared to the nebulization group, which is a statistically significant observation.

Keywords: Lignocaine, Nebulization, Endotracheal Intubation, Stress Response and Laryngoscopy

Edition: Volume 12 Issue 3, March 2023,

Pages: 763 - 767