International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Obstetrics and Gynecology | India | Volume 12 Issue 3, March 2023


A Prospective Study on Bacterial Colonization in Women with Preterm Premature Rupture of Membranes and its Maternal and Fetal Outcome in a Tertiary Care Centre

Dr. R. Rajarajeswari [4] | Dr. K. Dhivya | Dr. V. Bharathi


Abstract: Background: PPROM is a multifactorial entity and it is the main cause of preterm birth that can result in high perinatal mortality & morbidity along with maternal morbidity. With regard to the importance of maternal genital tract colonization as an etiological factor in PPROM, appropriate antibiotic therapy has a cardinal role in prevention & treatment of maternal & neonatal complications. The aim of this study is to identify the microbiota in women with PPROM by High vaginal swab & its antimicrobial sensitivity, and to study the risk factors, maternal and neonatal morbidity and mortality trends in PPROM. Methods: The study group includes 120 patients presenting with pPROM between 28-37weeks of gestation under the Department of Obstetrics and Gynaecology at Govt Raja Mirasudhar Hospital attached to Thanjavur Medical college and Hospital for a period of one year from January 2020 - December 2020. Results: In my study, the most common organism isolated was E.coli followed by Klebsiella, Pseudomonas, coagulase negative staphylococcus aureus and candida. Most of the organism isolated was sensitive to Amikacin and Gentamycin followed by cefotaxim and ciprofloxacin. Most of the patients had no risk factors for developing pPROM and the most common risk factors was breech presentation followed by previous history of pPROM. Most of the mothers had no complications and the most common maternal complication encountered was wound infection followed by chorioamnionitis. The most common neonatal complication was Respiratory distress syndrome followed by neonatal sepsis. Conclusion: PPROM is a fair complication of pregnancy that leads to various maternal and neonatal complications. So, the management of PPROM include hospitalization, administration of antibiotics to prevent infection, corticosteroid administration for fetal lung maturity, use of short term tocolytics till fetal lung maturity is achieved and active intervention to be done if infection is suspected or if labour is no longer preventable.


Keywords: Mac conkey agar, Blood agar, Muller Hilton Agar, Kirby Bauer method, E.coli, Klebsiella, Pseudomonas, coagulase negative s.aureus candida gentamycin, amikacin, chorioamnionitis, Respiratory distress


Edition: Volume 12 Issue 3, March 2023,


Pages: 682 - 687


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