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Research Paper | Pathology | India | Volume 12 Issue 3, March 2023

Evaluation of Peripheral Blood Smearand Bone Marrow Findings in Cases of Pancytopenia

Dr. Venkata Sai Praneetha G

Abstract: Background: Pancytopenia is the reduction in all three major formed blood elements; erythrocytes, leucocytes, and platelets. The severity of pancytopenia and the underlying pathology determines the management and prognosis. The present study was done to evaluate the peripheral blood film and bone marrow findings in cases of pancytopenia. Materials and methods: Out of 245 bone marrow studies done during the study period of 2 years (August 2020 to July 2022), 55 patients who presented with pancytopenia were included in the study. The clinical findings were taken from the hospital?s clinical records. Complete blood picture bone marrow aspiration and biopsy findings were retrieved from the data available and recorded. The available smears and histopathology sections were examined as and when required. Results: Among 55 patients studied, 32% of cases were seen in the age group of 41?60 years with male predominance (M/F 1.6: 1). The most common cause of pancytopenia was megaloblastic anemia (23.7%) followed by aplastic anemia (14.5%). Hematological malignancies though accounted for (21.8%) which included already diagnosed and treated cases and only 5 cases (9.1%) were diagnosed for the first time. Conclusion: The complete blood picture and bone marrow findings provide valuable information for diagnosing and managing pancytopenia patients.

Keywords: Pancytopenia; Megaloblastic Anemia; Bone marrow examination

Edition: Volume 12 Issue 3, March 2023,

Pages: 1010 - 1014