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Research Paper | Pharmaceutical Science | India | Volume 12 Issue 5, May 2023
Synthesis and Evaluation of Heterocyclic Derivative as Anti-Tubercular Agent
Abstract: Tuberculosis is considered a worldwide health problem mainly due to co-infection with HIV and proliferation of multi-drug resistant strains. Sparking recent interest in finding new antitubercular agents with different chemical scaffolds and mechanisms of action. Sparking recent interest in finding new antitubercular agents with different chemical scaffolds and mechanisms of action. Mycobacterium tuberculosis shikimate kinase (MtSK), an enzyme present in the shikimate pathway in bacteria, is essential for the survival of the tubercle bacillus, representing an ideal target for therapeutic intervention given its absence in mammals. The last step in this pathway is performed by chorismate synthase (CS), which catalyzes the conversion of 5-enolpyruvylshikimate-3-phosphate (EPSP) to chorismate. In summary, we report new drug scaffolds targeting the essential protein MtSK that can be more selective antitubercular drugs.
Keywords: Mycobacterium tuberculosis, Shikimate kinase, Chorismate synthase, Synthesis antitubercular drug, FT-IR, 13C NMR, 1H NMR, Mass Spectroscopy, In-silico studies, Biological testing, MABA Method
Edition: Volume 12 Issue 5, May 2023,
Pages: 810 - 819