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Research Paper | Medical Science | India | Volume 12 Issue 3, March 2023
Central Nervous System Manifestations and its Outcome in Dengue Fever
Dr. Dasu Praneeth
Abstract: Dengue is a major public health problem in East Godavari and surrounding districts in the state of Andhrapradesh in South India. Over the last few years, we have been observing varied clinical manifestations of dengue, which rather does not fulfill WHO criteria for making a diagnosis of severe dengue infections like DHF and DSS. A wide range of neurological manifestations were observed in our study. Altered sensorium, seizures, papilloedema, cranial nerve palsy, meningeal signs are among the common manifestations. Encephalitis is an important presentation in hospitalized children. Detection of dengue specific IgM in CSF using ELISA has high specificity and it is difficult to explain the presence of IgM antibody in the CSF other than by viral invasion across the blood brain barrier. In our study IgM in CSF was isolated in 17(35%) of cases, along with mean CSF protein of 84 mg/dl and with CSF mean cell count of 61cells/cmm3 which suggest viral invasion into the CNS. In endemic area dengue encephalitis should be considered in patients who present with the clinical features of encephalitis, whether or not classical manifestation of dengue is present. Standard case definition for dengue encephalitis, if adopted by WHO would help clarify the importance of dengue neurotropism world-wide.
Keywords: Dengue, Fever, CNS
Edition: Volume 12 Issue 3, March 2023,
Pages: 344 - 346