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Research Paper | Anaesthesiology | India | Volume 12 Issue 3, March 2023

Effect of Intrathecal Isobaric Levobupivacaine and Hyperbaric Bupivacaine in Lower Limb Orthopaedic Surgery - A Comparative Study

Yadav Manoj | Deka Bipul ^[3] | Borah Pollov ^[4]

Abstract: Background and aims: Levobupivacaine is less cardiotoxic and has less CNS side effects. This study aims to compare the intrathecal block characteristic, hemodynamic stability and adverse effect of isobaric levobupivacaine and hyperbaric bupivacaine in lower limb orthopedic surgery. Methods: 90 patients with ASA grade I /II between the age group 18-65 yrs under going lower limb orthopaedic surgery were included in this hospital based observational study. Patients were divided into two groups of equal size (n = 45). The patients were given spinal anaesthesia in sitting position and after confirmation of needle in the subarachnoid space the drugs were administered. Group B received 17.5 mg hyperbaric bupivacaine and Group L received 17.5 mg isobaric levobupivacaine. Both groups were compared regarding sensory-motor block characteristics, hemodynamic profile, adverse effects, supplemental analgesia and success rate. Results: Both agents produced effective spinal anesthesia to accomplish surgery without supplementation in all 90 (100%) patients. Onset of sensory and motor block was faster in bupivacaine. Duration of sensory and motor block and analgesia was longer in bupivacaine however there was no need for supplement analgesia during the intra operative period. Incidence of hypotension and side effects were less in levobupivacaine. Conclusion: Isobaric levobupivacaine is a suitable alternative to hyperbaric bupivacaine in spinal anesthesia as it provides effective sensory motor blockage and stable harmodynamic profile and significantly decreased cardiovascular and central nervous system toxicity.

Keywords: isobaric levobupivacaine, hyperbaric bupivacaine, subarachnoid block

Edition: Volume 12 Issue 3, March 2023,

Pages: 612 - 617