International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Medicine | India | Volume 12 Issue 3, March 2023


The Risk Factors for Nosocomial Sepsis in Neonatal Intensive Care Unit: Prospective Observation Study

Dr. Suruchi Shukla | Dr. Rohini Deshmukh | Dr. Anant Bendale [2] | Dr. Suyog Tannirwar [2] | Dr. Vikrant Deshmukh


Abstract: Background: Nosocomial infection is defined as an infection occuring at any site, which was acquired during hospitalization & results from inoculation of an organism that was not present or incubating in a patient at the time of admission. There are differences in reporting Nosocomial infections, particularly the timing of onset. Because neonatal Nosocomial infections are known causes of morbidity and mortality in all neonates but particularly in the smallest, the most immature infants, it is important to determine whether the infection risk is inherent to the infant or can be affected by environment and the treatment received in NICU. Aim: To determine the risk factors associated with development of nosocomial sepsis, clinical features, microorganisms, laboratory investigation, blood culture & sensitivity evaluation to incidence & mortality of nosocomial sepsis for better outcome of neonates in NICU. Material & Methods: This is Prospective observational study conducted at UPMC & Hospital, study population was all babies admitted in NICU over the period of 2 years showing clinical features of sepsis >48hrs of admission in whom laboratory investigations support the diagnosis. During the study period a total 625 neonates were admitted to NICU. All these neonates were screened for nosocomial sepsis. Out of all admitted neonates 140 met the inclusion criteria. Results: Incidence of nosocomial sepsis was 21.47%. Neonatal factors such as gender, weight, prematurity, asphyxia, resuscitation (bag and mask, ET intubation & 02 by nasal cannulation), number of needle pricks and TPN show statistically significant association with nosocomial sepsis. The maternal risk factors which showed significant statistical association were pregnancy induced hypertension and more than 3 vaginal examinations. Most commonly observed symptoms are lethargy (80%), icterus (69.29 %) and poor weight gain (65.71%). Lesser common manifestation include tachypnea (52.14%), refusal to suck (48.56%), abdominal distension (47.86%) & hypothermia (44.29%) and least common being irritability (12.86), sclerema (7.86%) and fever (6.43%). Mean duration of stay in NICU was 10.48 days. Conclusion: The most common organism isolated was klebsiella pneumonia followed by E. Coli followed by least common were streptococcus species. The mortality rate due to nosocomial sepsis was found to be 27.86%.


Keywords: Nosocomial Sepsis, NICU, Infection, Newborn, Prevention, CLABSI, VAP


Edition: Volume 12 Issue 3, March 2023,


Pages: 54 - 58


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