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Comparative Studies | Cancer Science | India | Volume 12 Issue 2, February 2023
Retrospective Study of Prognostics Factors in Operated Breast Cancer Patients in the Western Indian Population
Dr. Shilpa L. Chudasama [2] | Dr Taher Gandhi | Dr Mihir Joshi | Dr Ajith P.
Abstract: Breast cancer is among the most prevalent and growing malignant diseases among Indian women in the past three decades. This disease affects all physical, mental, and social aspects of women?s life. On the other hand, such as social and mental support during the illness can reduce the damage. This study investigates different factors and their association with recurrence in the form of locoregional and distant metastasis in operated cases of primary invasive breast carcinoma. Prognostic factors for the risk of breast cancer and subsequent recurrences or distant metastases (DM) breast cancer recurrence are well known. As current follow - up is still consensus - based, more information on the patterns and predictors of subsequent recurrences can inform more personalized follow - up decisions. [1]. Methods: Women diagnosed with invasive ductal breast cancer who were operated on with modified radical mastectomy (MRM) with curative intent were selected from the G. G. Hospital registry (N = 106). A retrospective study was undertaken to assess their likeliness of association with subsequent recurrences after MRM. Patients treated with lumpectomy, radical mastectomy, and other histopathological variants like lobular carcinoma, and medullary carcinoma were excluded from this study. Results: The risk of first recurrence was highest during the first - year post - diagnosis (39 percent). Out of 26 symptomatic patients, 20 patients were found positive for recurrence on CT follow - up scans. The rate of recurrence is found to be slightly higher in patients of the non completion group as compared to those that completed their chemotherapy cycles and statistically insignificant (p value=0.233). And patients of age less than 50 were found to have a higher association for the recurrence but statistically insignificant (parietal - value: 0.96). The majority of the patients were ER +, PR +, and Her 2 - ve with equal recurrence rates. Triple - negative patients showed higher rates of recurrence with an Odds ratio: of 4.7 and statistical significance (P value: 0.03). Conclusions: Higher recurrence rates in the first two years post ? surgery suggest more intensive follow - up and better modalities needed for early detection subsequent to primary treatment especially during the first 2 years. Most variables like IHC markers, age groups (age less than 50 or more than 50), and treatment completion known in various literature as established prognostic factors were found to be of no statistical significance (except for the data on the relation of triple - negative status emphasizing on its role as a poor prognostic marker) possibly due to cultural difference, literature deficiency and difficulty in accessing timely health care services in our region.
Keywords: Breast cancer, breast cancer risk factors, post - operative recurrence breast cancer, Breast cancer prognosis, breast cancer follow - up
Edition: Volume 12 Issue 2, February 2023,
Pages: 1068 - 1072