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Case Studies | Dermatology | India | Volume 12 Issue 2, February 2023 | Popularity: 4.3 / 10
Langerhans Cell Histiocytosis with Nail Involvement: A Rare Case
Dr. Prashant Deepak Ukey, Dr. Shreya Maniyar, Dr. Rachana Laul
Abstract: Langerhans cell histiocytosisis a proliferative disease characterized by excess accumulation of CD1a + Langerhans cells in various sites, leading to tissue damage. More common in males (m:f = 2:1) with estimatedprevalence of 2?5 children per million per year. Common sites involvedare skin, ears, periodontal, bone, lymph nodes, endocrine glands and lungs. Herein, we report a case of 3-year-old boy presenting with a hypopigmented maculopapular lesion in the seborrheic area and lymphadenopathy. Nail dystrophy was also present. Histopathological and immunohistochemical studies were suggestive of LCH. Langerhans cells histiocytosis is a rare disease with a high rate of misdiagnosis and definitive diagnosis depends on pathological biopsy and X-ray examination. The prognosis is related to the age of onset and the number of affected organs. Here we report a rare case of LCH with Nail dystrophy.
Keywords: Langerhans cell histiocytosis(LCH), Langerhans cell, Nail, Histopathology, Immunohistochemistry
Edition: Volume 12 Issue 2, February 2023
Pages: 982 - 983
DOI: https://www.doi.org/10.21275/SR23215170555
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