International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

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Case Studies | Dermatology | India | Volume 12 Issue 2, February 2023

Langerhans Cell Histiocytosis with Nail Involvement: A Rare Case

Dr. Prashant Deepak Ukey | Dr. Shreya Maniyar | Dr. Rachana Laul [3]

Abstract: Langerhans cell histiocytosisis a proliferative disease characterized by excess accumulation of CD1a + Langerhans cells in various sites, leading to tissue damage. More common in males (m:f = 2:1) with estimatedprevalence of 2?5 children per million per year. Common sites involvedare skin, ears, periodontal, bone, lymph nodes, endocrine glands and lungs. Herein, we report a case of 3-year-old boy presenting with a hypopigmented maculopapular lesion in the seborrheic area and lymphadenopathy. Nail dystrophy was also present. Histopathological and immunohistochemical studies were suggestive of LCH. Langerhans cells histiocytosis is a rare disease with a high rate of misdiagnosis and definitive diagnosis depends on pathological biopsy and X-ray examination. The prognosis is related to the age of onset and the number of affected organs. Here we report a rare case of LCH with Nail dystrophy.

Keywords: Langerhans cell histiocytosis(LCH), Langerhans cell, Nail, Histopathology, Immunohistochemistry

Edition: Volume 12 Issue 2, February 2023,

Pages: 982 - 983

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