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Research Paper | Pharmacology Science | India | Volume 12 Issue 2, February 2023
In vitro Anti - Arthritic Studies of Few Medicinal Plants having Traditional Claim for Treating Arthritis in Dakshina Kannada, Karnataka
Shakunthala .B | Shobha [58]
Abstract: Use of herbal medicine is becoming popular due to its less toxicity and side effects when compared to allopathic medicines. The plants such as Cardiospermum helicacabum, Kirganelia reticulata, Pongamia pinnata, Scoparia dulcis, Urena lobata and Vitex negundo acts as one of the important sources maintaining its place in treating arthritis with minimum scientific validation. Considerable studies have been carried out on these ethno medicinal plants but very few of them have attracted the interest of scientists, to investigate them as cure for arthritis. Our present work aims at investigating the in - vitro anti - arthritic effects of Cardiospermum helicacabum, Kirganelia reticulata, Pongamia pinnata, Scoparia dulcis, Urena lobata and Vitex negundo at various concentrations. The inhibition of protein denaturation, membrane stabilization and proteinase inhibitory action were taken as a measure of the in - vitro anti - arthritic activity. The same effects were investigated for the formulation prepared from these extracts. The maximum anti - arthritic effect was shown by Cardiospermum helicacabum and Kirganelia reticulata at dose dependent manner. This is followed by Urena lobata and Vitex negundo showing good effect, which is then followed by Pongamia pinnata and Scoparia dulcis. Interestingly the formulation had shown excellent effects when compared to standard acetyl salicylic acid. Therefore, our studies support the traditional usage of above plants for treating arthritis. This study not only confirms the ethnomedicinal use of above plants in the treatment of arthritis, but also indicates the strong anti - arthritic effects when culminated together. Additional clinical trials are however required further to show the effectiveness of formulation in different immuno - inflammatory conditions.
Keywords: protein denaturation, membrane stabilization, proteinase inhibitory action, formulation
Edition: Volume 12 Issue 2, February 2023,
Pages: 1206 - 1210