International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Paediatrics | India | Volume 12 Issue 2, February 2023


To Study the Influence of Technique of Surfactant Administration Lisa (Less Invasive Surfactant Administration) Vs. Insure (Intubate Surfactant Administration Extubate) on the Outcome of Respiratory Distress Syndrome Treatment in Preterm Infants (A Study of 100 Cases)

Dr. Agnes Puthussery | Dr. Bhadresh Vyas | Dr. Swathi R


Abstract: The incidence of Respiratory Distress Syndrome due to surfactant deficiency in premature infants is 50% in gestational age of 26-28 weeks to 25% in 30-32 week GA. Exogenous surfactant administration is the standard of care in these patients. This study is an observational retrospective + prospective longitudinal study. 100 preterm infants hospitalized in neonatology department and administered surfactant by LISA and INSURE technique for RDS were enrolled in the study as per inclusion criteria. An observation of the vitals before and after the procedure, along with the time required to administer the surfactant as well as the primary and secondary outcomes in infant were recorded. Results were analysed with help of standard statistical tests. The mean change in respiratory rate, heart rate, O2 saturation with LISA and INSURE were comparable. The mean procedural time with LISA was 8 +2 min, whereas with INSURE being 16+2 min (Z test: p value=<0.001). The incidence of mechanical ventilation within 72hrs of surfactant administration with LISA was 16% whereas with INSURE being 30% (Chi-square test: p=0.096). The average duration of hospital stay was 8+2 days with LISA and 14+2 days with INSURE (Z test: p=<0.001; significant). The mortality rate in LISA was 16% and with INSURE 30% (Chi-square test: p=0.049).


Keywords: surfactant therapy, RDS, LISA, INSURE


Edition: Volume 12 Issue 2, February 2023,


Pages: 894 - 897


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